ABSTRACT
The World Health Organization has unanimously accepted the four dimensions of complete human health: mental, physical, social, and spiritual. Due to the present pandemic of COVID-19, the mental and spiritual health of an individual is completely disturbed. The article is a trial enough to establish the effect of Sanskrit Vedic Mantra and Yajna, an ancient Hindu science of upliftment of consciousness and to heal self by sound science and heat and light. The article demonstrates the effect of mantra chanting on different ages and genders, rural and urban, and different age groups on human consciousness and mental peace and spiritual wellbeing. It presents the effect of sound science and mantra science over the human mind and body to relax after the stress of COVID-19, a nightmare for the world of the 21st century. Copyright © 2022, IGI Global.
ABSTRACT
Sustainable fashion is clothing that is ethically produced and environmentally beneficial, whereas rapid fashion is the polar opposite in terms of sustainability. We know that circular business models can drive value by improving customer attention and possession. Due of its environmental impact, fashion experts believe that "there is no such thing as 100 percent sustainable fashion. "During the Covid-19 crisis, this trend became notably apparent, with two-thirds of surveyed European customers admitting that minimizing climate change impacts had become increasingly essential to them. The future of Sustainability in Fast Fashion concept and concern with the Consumers Behavior where circular business models are incorporated to increase the efficiencies of system to reduce inputs and decrease the amount or flow of material & garments in the system to reduce waste. The current study focuses on sustainability in fast fashion in the textile industry, with a focus on five imperatives: prioritize based on market segment, match the business model to the product, get the incentives right, make sustainable and pilot and experiment © 2022, Man Made Textiles in India. All rights reserved.
ABSTRACT
Introduction/Background: COVID-19 disease, caused by SARS-CoV-2 virus, first emerged as a presentation of severe respiratory disease in 2019. Although children exhibit mild disease, concerns were raised about serious infection in immunocompromised children. The current national guidance recommends that immunocompromised children between 12 and 18 years of age should be offered three primary doses of the Pfizer BioNTech vaccine, 8 weeks apart, followed by a booster dose within 3 months. This audit looked at the awareness and uptake of this regime in young persons on immunosuppression. This information was disseminated to families during clinical contacts and automatic replies sent out from the team mailbox. Description/Method: To collect the data for the audit, we used an anonymous questionnaire to capture the following information:• Diagnosis• Immunomodulatory/Immunosuppressive treatment• Their awareness of the regime for COVID vaccine (number of doses and interval)• Number of vaccines taken• If not taken, why?The questionnaires were handed out to 31 patients attending Paediatric Rheumatology day-care and outpatient clinics over a two-week period for their response. There were no non-responders. Patients who were not on any immunosuppressant medication were excluded.The split of their diagnoses and medications are summarised in tables 1 and 2:Patients with JIA (55%) unsurprisingly dominated the cohort, followed by JSLE, JDM and scleroderma. Only 3/31 patients (10%) were on any form of systemic steroid therapy (all on oral Prednisolone less than 0.5 mg/kg). Majority of the patients (21/31 – 68%) were on Methotrexate, either on its own, or in combination with one of the biologic agents (one scleroderma patient was on MTX + MMF). 14/21 (45%) patients were on one of the biologic agents, of which only one patient was on Rituximab.P69 Table 1:Patients' diagnosesDiagnosisNumber of respondentsJuvenile Idiopathic Arthritis (JIA)17 (2 – uveitis) – 55%Juvenile Systemic Lupus Erythematosus (JSLE)5 – 16%Juvenile Dermatomyositis (JDM)3 – 10%Localised scleroderma / Systemic Sclerosis3 – 10%ANCA Associated Vasculitis (AAV)1 – 3 %Systemic Autoinflammatory Disease2 (both Mevalonate Kinase deficiency) – 6%P69 Table 2:Patients' medicationsMedicationsNumber of respondentsSystemic steroids (on top of other medicines)3 (10%)Methotrexate (MTX)11 (35%)Methotrexate + Adalimumab6 (19%)Mycophenolate Mofetil (MMF)4 (13%)MTX + MMF1 (3%)Adalimumab3 (10%)MTX + Infliximab3 (10%)Canakinumab 2 (6%)Cyclophosphamide1 (3%) Discussion/Results: The results showed that only 6/31 (19%) of patients/their carers knew the correct number (3 + 1) of COVID vaccines recommended in this cohort. 18/31 (58%) patients had received the vaccine, of which 4 patients refused further doses due to side effects they had experienced following the first dose. Of the 13 young people who did not take the vaccine, 9 patients (29%) were unsure whether they need the vaccine. They did not know the benefits of the vaccine and were afraid it either could have a negative effect on immunocompromised children or just were not aware of the guidelines. The other 4 (13%) participants did not want to take the vaccine due to their own personal beliefs.Although concerns were raised about serious COVID-19 infection in immunocompromised children, there is currently very little evidence to suggest that the infection rate and severity of COVID-19 infection in children treated with Methotrexate or biologic agents is higher or the treatment needs to be discontinued or the doses adjusted. There is some emerging evidence to suggest that adults on Rituximab and to a lesser extend Mycophenolate may have increased risk of developing severe outcomes from COVID-19, which has not been replicated in children. The recommendation for third primary dose is based on preliminary results from UK studies of real-world vaccine effectiveness (VE) in persons who are immunosuppressed, suggesting a modest reduction in VE against symptomatic COVID-19. There is also emerging evidence hat COVID vaccination significantly reduces the risk of Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) in 12 – 18 year olds. Key learning points/Conclusion: Despite the notion that the team had disseminated information on the vaccine regime to patients, only one fifth of the patients/carers knew the exact regime for COVID vaccine recommended in this group of young people.Just under 60% of the patients took the vaccine, with the rest choosing not to have it due to a mixture of lack of information and personal choice.The action plan was drawn up to:1. enquire about and document vaccination status, and provide advice and information during every clinical contact;2. include COVID vaccine in education sessions by nursing team;3. include the information as default in all clinic letters;4. reaudit in six months.
ABSTRACT
Background: COVID-19 poses a great challenge to the global health Care system all over the world. The contribution of your frontline worker toward defeating the pandemic is immeasurable on the other hand the health care professional also burdens up and faces disturbance in the mental and physical health. Methodology: Study was conducted with an objective to assess the mental health and coping strategies used by health professionals during COVID-19 Pandemic. A cross sectional survey design was used and sample was collected by Snowball sampling technique from different state and union territories of India. A total 106 healthcare professionals responded and enrolled themselves in the study. Result: in present study most of the participants 53(50.0%) reported moderate depression, 53(50.0%) moderate anxiety and 49 (46.2%) had mild stress. The data analysis reported that maximum numbers of participants had access to psycho-educational material like leaflet, brochure and books provided by the institution (60.4%) compared to (39.6%) who did not get this privilege, next, majority of the participant (76.4%) had availability of resources like internet, TV, newspaper, social media etc. More than half of the participants were able to avail counselling services (55.7%), psychotherapy (63.2%) etc. Conclusion: This pandemic has led to anxiety, stress, depression and other mental health issues among the people especially in health care profession. Mental health problems like stress, anxiety and depression can adversely affect the physical health of the health professionals as well as their competency to care for sick.
ABSTRACT
Background:Today the whole world is facing the outbreak of Covid-19 disease. People were forced to remain imprisoned in their home, be it a service class, farmer, businessman or student. Due to Covid-19 Pandemic era, schools and colleges are closed. Every student is feeling stressed and waiting for permanent treatment of this disease so that the conditionsbecomes suitable and the studies shall begins in normal pace again. This study is aimed to assess the perceived stress among medical under graduate students and their methodstocopeup this stress in their own way. Materials and Methods: This cross-sectional observational online study was done in august 2020. Participants were MBBS undergraduate Students, whose perceived stress and coping strategies related to Covid-19 era, were assessed using an online questionnaire(Cohen's PSS 10 scale) through Google forms. Total PSS Score was categorised into three parts as low, moderate and high. Coping measures were categorised separately according to their responses. Results: A total of 145 students took part in study. Mean±SD of total perceived stress score was found to be 21.703± 6.564, for male 20.61 and for female 23.21. Stress level was found more in females as compared to male participants. They used different typesof measures for coping out the perceived stress due to covid-19conditions. P-value of correlation of PSS with coping and lifestyle pattern was found to be 0 .440 and 0.011 respectively. Conclusion:This study indicates that,in all 71.03 % medical students were in moderate level of perceived stress, where 42.07% were males and 28.96% were females. They opted various measures to cope up the stress which leads to change in their lifestyle pattern. Mostly, students reported sleep cycle disturbancewhich further increased their stress level. Hence there is amuch needed demand of current time to take immediate action to reduce stress level in medical students.
ABSTRACT
In recent years, it has been reported that many herbal plants contain antiviral agents which combat a human disease that is caused by pathogenic viruses. The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in the prevention of viral disorders. On the basis of randomized controlled studies and in-vivo studies, and in-vitro studies, some agents are utilized all across the globe. Progressively numerous studies on therapy of antivirals have been increased. Though, efficacy remains disputable for antiviral drugs that are employed for viral disorders. The viral diseases are challenging for the health of people around the world cause significant increase in mortality and enhance crises. There are many synthetic antiviral drugs that have a large number of side effects and have narrow therapeutic window range, while in the other hand herbal formulations have minimized side effects. The advantages of herbal formulation over synthetic drugs encourage us to devise and expand new herbal moieties against the emerging viral infections. The medicinal plants contain phytochemicals that have antiviral properties. In this paper, the activity of antiviral agents from medicinal plants which have importance in Ayurveda, are discussed along with their source.
ABSTRACT
This case study describes a 45-year-old Caucasian male with a past medical history of obesity, hypertension, and non-insulin-dependent diabetes mellitus, who in the setting of coronavirus disease 2019 (COVID-19) pneumonia, developed portal vein thrombosis (PVT) presenting as an acute abdomen after hospital discharge from a cholecystitis episode. PVT is a very infrequent thromboembolic condition, classically occurring in patients with systemic conditions such as cirrhosis, malignancy, pancreatitis, diverticulitis, autoimmunity, and thrombophilia. PVT can cause serious complications, such as intestinal infarction, or even death, if not promptly treated. Due to the limited number of reports in the literature describing PVT in the COVID-19 setting, its prevalence, natural history, mechanism, and precise clinical features remain unknown. Therefore, clinical suspicion should be high for PVT, in any COVID-19 patient who presents with abdominal pain or associated signs and symptoms. To the best of our knowledge, this is the first report of COVID-19-associated PVT causing extensive thrombosis in the portal vein and its right branch, occurring in the setting of early-stage cirrhosis after a preceding episode of cholecystitis.
ABSTRACT
Background: Neutralizing antibodies cocktail (Casirivimab and Imdevimab) has received conditional recommendation by FDA and WHO for mild to moderate COVID infection in specific high-risk groups. Persons with underlying chronic illnesses are at high risk of developing severe disease. The effectiveness of various repurposed drugs approved for the management is variable. Antibodies cocktail has shown promising results in preventing progression to severe disease. But the data about its use and safety from India is scarce. Herein, we present a retrospective analysis of 10 patients who were administered with the antibodies cocktail between Aug 2021 and Oct 2021. Methodology: We conducted an observational retrospective analysis of clinico-radiological, inflammatory parameters, progression of the disease, and outcome amongst ten mild and moderate COVID 19 patients treated with antibodies cocktail. Results: Ten patients were administered the antibodies cocktail (casirivimab 600 mg and Imdevimab 600 mg). The median age was 63.5 years, and four patients were partially vaccinated, and the rest were unvaccinated. Diabetes and hypertension were the commonest comorbidities;hematological and solid organ malignancies were other comorbidities. The median CRP level on admission was 91.5 mg/dL. Other inflammatory markers like neutrophil: lymphocytes ratio, ferritin, and LDH were higher than normal limits. None of our patients required supplemental oxygen or progressed to severe ARDS nor has any adverse reactions. All patients were discharged in a stable condition within six days of the therapy. Four patients had radiological opacities consistent with COVID 19 pneumonia and had shown regression after the therapy. The observation indicates that this therapy may also be effective in the early pulmonary phase of the disease. Conclusions: The neutralizing antibodies cocktail has shown encouraging results in our analysis in preventing progression to severe disease and is not associated with severe adverse reaction.
ABSTRACT
To assist the COVID-19 focused researchers in life science and healthcare in understanding the pandemic, we present an exploratory information retrieval system called RCES. The system employs a previously developed EVE (Explainable Vector-based Embedding) model using DBpedia and an adopted model using MeSH taxonomies to exploit concept relations related to COVID-19. Various expansion methods are also developed, along with explanations and facets that collectively form rapid cues for a valuable navigational and informed user experience. © 2021 Owner/Author.
ABSTRACT
Terminalia Chebula has been extensively used in field of traditional medicine and AYUSH. Recent Studies using fluorescence analysis given a sense of understanding of Terminalia Chebula fruit pulp. Present study is to carry out preliminary phytochemical screening of EEFTC fruit pulp and the Medicinal values . Terminalia Chebula dried fruit The ethanolic extracts were concentrated in Roto flash evaporator and dried and stored in freezer for further biochemical analysis by using screening methods like preparation of smoothie, Phytochemical analysis, evaluation of determination of crude fibre content and antimicrobial activity of plant extracts, Qualitative Phytochemical analysis, we found that the, aqueous, ethanolic extract of T. Chebula (EETC) is rich with all the compound like Phytosterols, Triterpenoids, Carbohydrate, Glycosides, Phenolic compound . The antimicrobial activity index of extracts of Terminalia Chebula dried fruit pulp at different concentrations was also investigated, the antimicrobial activity, indicated by an inhibition zone surrounding the well containing the extract, was recorded if the zone was greater than 8 mm. Terminalia Ch ebula contains biomolecules which already shown the have anti‐viral, anti‐inflammatory, anti‐oxidant properties, against many pathogen microorganism . in present situation of pandemic outbreak, an expedited screening of therapeutically bioactive constituents is required to establish the anti‐SARS‐CoV‐2 property of these herbs.
ABSTRACT
The COVID-19 is an ongoing global crisis. To deal with it efficiently, health-care system has to gear up to the increasing burden by judicious use of workforce and resources. In the perioperative setting, adequate preventive measures are of prime importance to prevent infection spread among health-care workers. The knowledge regarding the disease is still evolving. In this article, we have outlined the basic epidemiology, pathology, presentation, and diagnosis of COVID-19 along with the considerations for operating room preparedness, personal protective equipment required, airway management, anesthesia conduct, and perioperative concerns when managing positive or suspected COVID-19 pediatric patients and have suggested ways to overcome potential hindrances based on available literature. We have also deliberated upon the specific considerations for a COVID child undergoing regional anesthesia and critically ill COVID-19 pediatric patients. Careful adaptation of working principles based on local needs can help in the prevention of disease spread when optimizing care to the patients.
ABSTRACT
Aims & Objectives: In our study differences detected in hematological parameters between severe and non-severe patients and A blood workup as well as continuous tracking hematological changes can reveal the risks of disease progression so that patients at high risk can identify and guide more appropriate critical care. Patients/Materials & Methods: We analysed prospectively haematological parameters of 850 COVID19 cases with laboratory confirmation during may 2020 to September 2020 at RUHS College of Medical Sciences, Jaipur. Results: When the disease progresses to severe stage, lymphopenia continues to aggravate. Increased neutrophil count and neutrophil-tolymphocyte ratio, and decreased haemoglobin concentration were identified as the risk factors of severe illness in patients with SARSCoV- 2 infection. Elevated DDimer levels are consistently reported, whereas their gradual increase during disease course is particularly associated with disease worsening. Other coagulation abnormalities such as PT and aPTT prolongation, fibrin degradation products increase, with severe thrombocytopenia lead to lifethreatening disseminated intravascular coagulation (DIC), which necessitates continuous vigilance and prompt intervention. Discussion & Conclusion: Hematological abnormalities are not rare in COVID-19 patients including lymphopenia, neutrophilia, thrombocytopenia, and decline of haemoglobin. The activation of monocyte-macrophage system aggravates the immune damage of lung and other tissues, which leads to the increase of D-dimer, prothrombin time, and platelet consumption. Study indicate the onset of inflammatory cytokine storms in COVID-19 lead to progress to severe lung injury, respiratory distress, and multiple organ failure.
ABSTRACT
The Internet of Things (IoT) has been gaining attention in various disciplines ranging from agriculture, health, industries and home automation. When a pandemic first breaks out early detection, isolating the infected, and tracing the contacts are the most important challenges. IoT protocols like Radio-frequency identification (RFID), Wireless Fidelity (WiFi), Global Positioning System (GPS) are gaining popularity for providing solutions to these challenges. IoT based applications in the health sector are benefitting COVID-19 (coronavirus disease of 2019) patients during this pandemic situation. This article explores and reviews the various Internet of Things enabled technologies and applications used in screening, contact tracing, and surveillance. IoT based telemedicine processes are very useful during the pandemic COVID-19. The purpose of this paper is to deliver an overall understanding of the existing and proposed technologies of IoT based solutions to make the situations better during COVID-19. © 2020 IEEE.
ABSTRACT
World Health Organization (WHO) has already declared the COVID-19 caused by SARS-CoV-2 as the pandemic of the year 2020, after its first outbreak reported in Wuhan, China. There have been numerous efforts laid upon by respective Governments in order to contain and mitigate the spread of the virus. One of the primary initiatives in this direction was to ascertain the number of cases through testing. Testing for the diagnosis of the COVID-19 is a crucial factor to know the prevalence, spread and transmissible nature of the disease. Moreover, how effective the testing strategy is prerequisite for knowing the exact number of infected cases by COVID-19. In India, 1,58,49,068 samples have been tested, out of which 13,36,861 samples have been found to be positive up to 24th July 2020. The testing strategy adopted by India has yielded fruitful and effective results so far when compared to nations like United States, United Kingdom, Spain and Italy. Current article focuses upon the dire need to upsurge testing in accordance to daily cases identified testing based on the macro and micro analysis of Covid-19 data in Indian scenario including all the Indian States and Union Territories. This article might give some due insights into enhancing the testing capabilities as well as testing strategies so as to contain the spread of the Covid-19 Pandemic. Considering that India has started to unlock with Unlock 1.0 and Unlock 2.0, the Covid-19 pandemic has started to disseminate to rural population and smaller cities have shown significant rise in Covid-19 infections. Therefore, testing across the whole nation and especially testing of travellers from hotspot zones has become a necessity else, community transmission looks inevitable and India would be at the edge of a pandemic within a pandemic within a couple of months.
ABSTRACT
Alarming situation has been caused due to the emergence of COVID-19 infection around the world. There is an urgency of developing a therapeutic strategy in order to control the spread of COVID-19. Towards that initiative, potential drugs like hydroxychloroquine, ivermectin and azithromycin have been tested by diverse group of researchers worldwide for their potential against novel coronavirus. The present report presents together the comprehensive knowledge derived from the major researches about the above drugs altogether in context of the current health emergency around the world. Hydroxychloroquine and ivermectin were known to act by creating the acidic environment and inhibiting the importin (IMPα/ß1) mediated viral import. Azithromycin was found to act similar to the hydroxychloroquine as an acidotropic lipophilic weak base. All the three categories of drugs seemed to potentially act against novel coronavirus infection. However, their efficacies need to be studied in detail individually and in combination in-vivo in order to combat COVID-19 infection.
ABSTRACT
Introduction: Severe acute respiratory syndrome due to coronavirus disease (COVID-19) has overwhelmingly affected the health-care systems globally. Delivering cardiovascular care has become unusually difficult both for caregivers and physicians in these unprecedented times. Methods: We briefly reviewed how cardiac care can be delivered to patients while limiting the exposure of both patients and healthcare workers through telemedicine services. We made a comparison at our institute of outpatient services through routine and telemedicine visits. Results: We found that telemedicine can be an equally effective alternative cardiac care during the times of pandemic with no significant difference in patients profile admitted through tele-medicine services. Conclusions: We concluded that telemedicine can prove to be an effective tool in delivering cardiac care by limiting exposure of both patients and physicians with better triage of cardiac patients in the situation of COVID-19 pandemic and may complement to regular cardiac care in routine times. © 2020 Sociedad Colombiana de Cardiología y Cirugía Cardiovascular.